Gene-Gene and Gene-Environment Interaction

Biological processes that can lead to the development of a disease are usually composed of both gene products and environmental factors. In particular, interactions between several genes or between genes and the environment therefore also play an important role in the development of disease.

However, interactions are unfortunately very difficult to detect, as the statistical tests that exist for this purpose either have too little power - especially in a genome-wide context, or have problems with compliance with the first kind error.

Therefore, we are working on developing better methods to detect interactions as well. Examples are gene-radon interaction (see lung cancer and radon), gene-time interaction (see psychosis) and gene-gene interaction in pathways (see GWAS pathways).

Last updated March 2023